THE IMPORTANCE OF METHYLATION
Did you ever wonder WHY all of a sudden someone develops a neurodegenerative disorder, heart disease, an autoimmune condition, suffer a stroke or even…develop cancer?
Did it just drop down out of the sky and land on their head?
No! They expressed a “mutated gene!”
How do you express “mutated genes” like autoimmune, MS, ALS, Parkinson’s,
heart disease or cancer?
The answer is depleted methyl groups! Depletion of your body’s methyl groups is how “mutated” genes are expressed.
How are methyl groups in our body depleted? By consuming a poor diet loaded with “white death”—white sugar, white flour, and white salt, “bad oils”—trans-fatty acids and hydrogenated oils, produce loaded with pesticides and herbicides, junk food, drinks loaded with caffeine, high-fructose corn syrup and acid, genetically-modified foods, and high levels of emotional stress!
Methylation is VERY important for the following processes to occur in our body:
- DNA/RNA synthesis (turning on/off genes)
- Brain chemical production (e.g. dopamine and serotonin)
- Hormonal breakdown (e.g. estrogen and testosterone)
- Creation of immune cells (e.g. NK cells and T-cells)
- Creation of protective coating on nerves (i.e. myelin formation)
- Processing of chemicals and toxins (detoxification)
- Produces Energy
When poor methylation occurs in our body, here is what can happen:
- Thyroid Disorders
- Neurological Disorders…Parkinson’s, tremor disorder, MS, Alzheimer’s, dementia, peripheral neuropathy, migraines and cluster headaches
- Hormonal regulation issues such as PMS, ovarian cysts, fibroids, PCOS in women or low testosterone in men
- Autoimmune disorders and Immune deficiency
- Chemical sensitivities and allergies
- Chronic Fatigue Syndrome
- Chronic Pain Syndromes (neck, back, shoulder, knee, etc.)
- ADHD, Autism, Asperger’s syndrome, dyslexia, and learning disabilities
- Frequent Miscarriages
- Lyme Disease
- Chronic Infections (Candida, parasites, bacterial, viral, etc.)
- Gut issues (IBS, Ulcerative Colitis, Crohn’s, chronic diarrhea or constipation)
- Heart Disease
- Stroke Rehabilitation
Understanding the basics
We have two copies of most of the genes we are born with – one from our mother and one from our father. This report assess the SNPs (Single Nucleotide Polymorphisms) generated from your unique DNA sequence to determine if one or both copies of your genes have a mutation at a specific location in a specific gene. If there are no mutations present, your result will be displayed as (-/-). If one gene is mutated, the result will read (+/-). If both copies have a mutation, the result is (+/+).
The terms heterozygous and homozygous are used by geneticists to denote whether one or both copies of a gene are mutated. Heterozygous mutations (+/-) may differ from homozygous mutations (+/+) in associated disease risk since a person with a heterozygous mutation will often still have one fully functioning copy of the gene. It is also important to understand that having a gene with a SNP mutation does not mean that the gene is defective or nonfunctioning, only that it is working with an altered efficiency. Sometimes this means that it working at a decreased level, but it could also mean that it is functioning at a higher than normal efficiency, or that the gene is lacking regulatory mechanisms normally involved in its expression. Although mutations can occur at any time during our lifetime, it is most likely that we are born with these mutations and will have them throughout our life. These inherited mutations have been passed down to us from previous generations (our parents and grandparents) and may be passed to future generations (our children). This may provide an explanation as to why certain traits or diseases “run in the family”. Although we cannot change our genetic code, we can change how our genes are expressed. Research has revealed that our gene expression is not determined solely by hereditary factors, but it is also influenced by our diet, nutritional status, toxic load and environmental influences or stressors. This phenomenon has been termed “epigenetics”. Researchers in the growing field of epigenetics have demonstrated that certain genes can be over or under-expressed with certain disease processes. Researchers in this field hope that by understanding of how these genes are regulated and what is influencing them, we may be able to change their expression. Using epigenetic concepts along with a good understanding of the methylation cycle, researchers have begun to make recommendations to optimize genetic expression and help to restore health.
What is a SNP?
SNP aka Single Nucleotide Polymorphism are variants that naturally occur on genes, causing changes in their functions. Some SNPs determine characteristics such as hair, eye, and skin color. While other SNPs have functional effects on ones genes, therefore can give insight on how well your body performs key functions that can affect your health and wellness.
Disclaimer: The information on this report is for informational purposes only. This information is not intended for the diagnosis, treatment or cure of disease.
Your Specific Genetic Profile
The key is to look at your mutations that correlate to symptoms you may be expressing. “TREAT THE PATIENT, NOT THE SNP!” The genes in your report are a starting point in supporting chronic neurological and metabolic conditions.
Key Points to Remember
- You do not necessarily need to worry about all of these mutations, but certain mutations may cause problems in certain individuals.
- Keep in mind that even if you are homozygous or heterozygous for a certain mutations, it doesn’t necessarily mean there is a problem with the functioning of that gene
- The problem may not be the SNP/gene, but rather a cofactor or substrate. Lifestyle and dietary changes are necessary.
- The majority of the time other issues need to be addressed prior to supporting genetic mutations/SNPs from these reports. ie. inflammation, oxidative stress, Nitric Oxide pathways, dietary changes/restrictions, gut and other barrier system repair, blood sugar, anemias, heavy metals, toxins, infections, etc. Just because a gene is mutated does not mean that you have a disease or pathology.
- Many of the genes in the complete report are still being research and we have limited clinical insight on some of the genes.
- The goal is not to put support in for every genetic mutation/SNP in these reports.
We will come back to this report for deeper questions/layers to your health as well as for preventative options